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Vitamin D Antenatal Asthma Reduction Trial

A collaboration between Boston University, Brigham & Women's Hospital, Harvard Medical School, Kaiser Permanente Southern California Region, Medical University of South Carolina, Washington University in St. Louis, and the NHLBI



Background Publications
Here are provided references to the publications that influenced the creation of the VDAART Trial.

  • 1. Childhood asthma may be a consequence of vitamin D deficiency.
    Litonjua AA.
    Curr Opin Allergy Clin Immunol. 2009 Jun;9(3):202-7. Review. PubMed PMID: 19365260
  • 2. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica.
    Brehm JM, Celed´┐Żn JC, Soto-Quiros ME, Avila L, Hunninghake GM, Forno E, Laskey D, Sylvia JS, Hollis BW, Weiss ST, Litonjua AA.
    Am J Respir Crit Care Med.
    2009 May 1;179(9):765-71. Epub 2009 Jan 29. PubMed PMID: 19179486;
    PubMed Central PMCID: PMC2675563.
  • 3. Is vitamin D deficiency to blame for the asthma epidemic?
    Litonjua AA, Weiss ST.
    J Allergy Clin Immunol. 2007 Nov;120(5):1031-5. Epub 2007 Oct 24.
    PubMed PMID: 17919705.


VDAART Publications
Here are references to the articles that resulted from the VDAART trial.
  • 1. Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial. Litonjua AA, Carey VJ, Laranjo N, Harshfield BJ, McElrath TF, O'Connor GT, Sandel M, Iverson RE Jr, Lee-Paritz A, Strunk RC, Bacharier LB, Macones GA, Zeiger RS, Schatz M, Hollis BW, Hornsby E, Hawrylowicz C, Wu AC, Weiss ST. JAMA. 2016 Jan 26;315(4):362-70. doi: 10.1001/jama.2015.18589. PubMed PMID: 26813209.
  • 2. Early pregnancy vitamin D status and risk of preeclampsia. Mirzakhani H, Litonjua AA, McElrath TF, O'Connor G, Lee-Parritz A, Iverson R, Macones G, Strunk RC, Bacharier LB, Zeiger R, Hollis BW, Handy DE, Sharma A, Laranjo N, Carey V, Qiu W, Santolini M, Liu S, Chhabra D, Enquobahrie DA, Williams MA, Loscalzo J, Weiss ST. J Clin Invest. 2016 Dec 1;126(12):4702-4715. doi: 10.1172/JCI89031. PubMed PMID: 27841759; PubMed Central PMCID:PMC5127689
  • 3: Factors influencing the infant gut microbiome at age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART). Sordillo JE, Zhou Y, McGeachie MJ, Ziniti J, Lange N, Laranjo N, Savage JR, Carey V, O'Connor G, Sandel M, Strunk R, Bacharier L, Zeiger R, Weiss ST, Weinstock G, Gold DR, Litonjua AA. J Allergy Clin Immunol. 2016 Oct 13. pii: S0091-6749(16)31134-4. doi: 10.1016/j.jaci.2016.08.045. [Epub ahead of print] PubMed PMID: 27746239.
  • 4. The Role of Vitamin D in the Transcriptional Program of Human Pregnancy. Al-Garawi A, Carey VJ, Chhabra D, Mirzakhani H, Morrow J, Lasky-Su J, Qiu W, Laranjo N, Litonjua AA, Weiss ST. PLoS One. 2016 Oct 6;11(10):e0163832. doi: 10.1371/journal.pone.0163832. PubMed PMID: 27711190; PubMed Central PMCID: PMC5053446. PMCID:PMC5053446


VDAART Publications - In press
Here are references to the articles that resulted from the VDAART trial.
In Press
  • 1. Vitamin D supplementation during pregnancy: impact on the neonatal immune system in a randomized controlled trial. Hornsby E, Pfeffer PE, Laranjo N, Cruikshank W, Tuzova M, Litonjua AA, Weiss ST, Carey VJ, O'Connor GT, Hawrylowicz C. J Allergy Clin Immunol 2017 (In Press).
  • 2. Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: Secondary analyses from the Vitamin D Antenatal Asthma Reduction Trial. Wolsk HM, Harshfield BJ, Laranjo N, Carey VJ, O'Connor T, Sandel M, Strunk RC, Bacharier LB, Zeiger RS, Schatz M, Hollis BW, Weiss ST, Litonjua AA. J Allergy Clin Immunol 2017 (In Press).